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Chemical Structure : PZ-1922
Catalog No.: PC-21667Not For Human Use, Lab Use Only.
PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.
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PZ-1922 is a potent, triple-acting 5-HT6R/5-HT3R antagonist and MAO-B reversible inhibitor with Ki of 17/0.45 nM (5-HT6R/5-HT3R), and pIC50 of 8.93 for MAO-B.
PZ-1922 reversed scopolamine-induced cognitive deficits in the novel object recognition test. Furthermore, it displayed superior pro-cognitive properties compared to intepirdine (a 5-HT6R antagonist) in the AD model.
PZ-1922, but not intepirdine, restored levels of biomarkers characteristic of the debilitating effects of oAβ.
| M.Wt | 376.89 | |
| Formula | C22H21ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Katarzyna Grychowska, et al. J Med Chem. 2023 Nov 9;66(21):14928-14947.
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