You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Antifolate-Pemetrexed
Pemetrexed

Chemical Structure : Pemetrexed

CAS No.: 137281-23-3

Pemetrexed (LY231514;LY 231514;LY-231514)

Catalog No.: PC-42709Not For Human Use, Lab Use Only.

A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively.

Packing Price Stock Quantity
100 mg $56 In stock
500 mg $135 In stock

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.

Chemotherapeutic Agents

Approved

Physicochemical Properties

M.Wt 427.4106
Formula C20H21N5O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in H2O

Chemical Name/SMILES

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

References

1. Shih C, et al. Cancer Res. 1997 Mar 15;57(6):1116-23.

2. Tonkinson JL, et al. Cancer Res. 1999 Aug 1;59(15):3671-6.

3. Curtin NJ, et al. Lancet Oncol. 2001 May;2(5):298-306.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: