Chemical Structure : Pemetrexed
CAS No.: 137281-23-3
Catalog No.: PC-42709Not For Human Use, Lab Use Only.
Pemetrexed (LY231514) is a classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively.
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|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $88 | In stock | |
| 250 mg | $138 | In stock | |
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Pemetrexed (LY231514) is a classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively.
Pemetrexed increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.
| M.Wt | 427.4106 | |
| Formula | C20H21N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in H2O |
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| Chemical Name/SMILES |
L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- |
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1. Shih C, et al. Cancer Res. 1997 Mar 15;57(6):1116-23.
2. Tonkinson JL, et al. Cancer Res. 1999 Aug 1;59(15):3671-6.
3. Curtin NJ, et al. Lancet Oncol. 2001 May;2(5):298-306.

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