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Request The Product List ofAntifolate Antifolate

Cat. No. Product Name CAS No. Information
PC-63364

TNP-351

125991-51-7 TNP-351 is an antifolate compound that functions as a DHFR inhibitor, strongly inhibits the growth of Meth A cells.
PC-62007

LSN 3213128

1941211-99-9 LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT; results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines; demonstrates tumor growth inhibition in a murine based xenograft model of triple negative breast cancer (TNBC); Aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) is an enzyme in the purine biosynthetic pathway.
PC-60506

Arfolitixorin

31690-11-6 A novel antifolate modulator compound.
PC-45348

Calcium N5-methyltetrahydrofolate

26560-38-3 The calcium salt of levomefolic acid that has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
PC-42590

Pralatrexate

146464-95-1 An antifolate that fuctions as a dihydrofolate reductase inhibitor for treatment of several malignancies.

Chemotherapeutic Agents

Approved

PC-42556

Trimetrexate

52128-35-5 A quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor; shows activity against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.

Chemotherapeutic Agents

Discontinued

PC-42710

Pemetrexed disodium

150399-23-8 A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.

Chemotherapeutic Agents

Approved

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