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Chemical Structure : Peretinoin
CAS No.: 81485-25-8
Catalog No.: PC-42023Not For Human Use, Lab Use Only.
A novel orally available, synthetic retinoid with potential antineoplastic and chemopreventive activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $280 | In stock | |
| 50 mg | $680 | In stock | |
| 100 mg | $1040 | In stock |
Bulk size, bulk discount!
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A novel orally available, synthetic retinoid with potential antineoplastic and chemopreventive activities; inhibits DEN-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation; decreases the levels of cyclin D1, cyclin D2, cIAP2 and XIAP proteins, and inhibits growth of ATL cells both in vitro and in vivo; prevents the progression of NASH and the development of HCC through activating the autophagy pathway by increased Atg16L1 expression in mice model; also inhibits HCV replication and infectious virus release in vitro.
Liver Cancer
Phase 3 Clinical
| M.Wt | 302.451 | |
| Formula | C20H30O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 100 mg/mL; In vivo: Peretinoin is dissolved in DMSO (3 mg/mL) and then diluted with water (DMSO: water=1:1). |
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| Chemical Name/SMILES |
2,4,6,10,14-Hexadecapentaenoic acid, 3,7,11,15-tetramethyl-, (2E,4E,6E,10E)- |
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1. Kagawa M, et al. Carcinogenesis. 2004 Jun;25(6):979-85.
2. Okudaira T, et al. Mol Cancer Ther. 2006 Mar;5(3):704-12.
3. Shimakami T, et al. Sci Rep. 2014 Apr 15;4:4688.
4. Okada H, et al. Oncotarget. 2017 Jun 20;8(25):39978-39993.
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