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Ph-HTBA

Chemical Structure : Ph-HTBA

CAS No.: 2368927-41-5

Ph-HTBA

Catalog No.: PC-49435Not For Human Use, Lab Use Only.

Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ph-HTBA is a mid-nanomolar affinity (Ki=78nM), brain permeable ligand of CaMKIIα hub domain binding site.
Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice.
Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development.
Ph-HTBA reduces Ca2+-stimulated CaMKIIα Thr286 autophosphorylation in primary cortical neurons and substrate phosphorylation of recombinant CaMKIIα, potentially contributing to its neuroprotective effect.

Physicochemical Properties

M.Wt 294.350
Formula C19H18O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-(5-Hydroxy-2-phenyl-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-ylidene)acetic acid

References

1. Tian Y, et al. J Med Chem. 2022 Nov 8. doi: 10.1021/acs.jmedchem.2c00805.

2. Griem-Krey N, et al. Biomed Pharmacother. 2022 Oct 20;156:113895.

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