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Chemical Structure : Pifithrin-β
CAS No.: 60477-34-1
Catalog No.: PC-45047Not For Human Use, Lab Use Only.
A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $75.2 | In stock | |
| 50 mg | $308 | In stock |
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A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
| M.Wt | 268.3766 | |
| Formula | C16H16N2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)- |
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1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.
3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
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