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Chemical Structure : Pirepemat
Catalog No.: PC-38369Not For Human Use, Lab Use Only.
Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
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Pirepemat (IRL752) is a new phenyl-pyrrolidine derivative and cognition-promoting agent with regioselective central nervous system transmission-enhancing properties, enhances norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex.
Pirepemat (IRL752) normalized tetrabenazine-induced hypoactivity, whereas it was unable to stimulate basal locomotion in normal animals or either accentuate or reverse hyperactivity induced by amphetamine or MK-801.
IRL752 induced but minor changes in monoaminergic tissue neurochemistry across noradrenaline (NA)- and dopamine (DA)-dominated brain regions.
| M.Wt | 213.228 | |
| Formula | C11H13F2NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Svenningsson P, et al. Mov Disord. 2020 Jun;35(6):1046-1054.
2. Hjorth S, et al. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.
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