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Chemical Structure : Pixatimod
Catalog No.: PC-72855Not For Human Use, Lab Use Only.
Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase.
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Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase.
PG545 is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models.
PG545 is a potent inhibitor of Th1/Th17 effector functions and inducer of FoxP3+ Treg.
PG545 is a highly potent inhibitor of angiogenesis, tumor growth, and metastasis currently in clinical trials for cancer.
| M.Wt | 2078.1 | |
| Formula | C51H88O60S13 | |
| Appearance | Solid | |
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1. Chhabra M, et al. Bioconjug Chem. 2021 Nov 17;32(11):2420-2431.
2. Kinaneh S, et al. Biosci Rep. 2021 Jul 30;41(7):BSR20210290.
3. Hammond E, et al. Adv Exp Med Biol. 2020;1221:539-565.
4. Dredge K, et al. Br J Cancer. 2018 Apr;118(8):1035-1041.
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