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Chemical Structure : Plevitrexed
Catalog No.: PC-49047Not For Human Use, Lab Use Only.
Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.
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Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.
| M.Wt | 532.53 | |
| Formula | C26H25FN8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jackman AL, et al. Clin Cancer Res. 1997 Jun;3(6):911-21.
2. Jackman AL, et al. Adv Exp Med Biol. 1994;370:185-8.
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