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Chemical Structure : Plocabulin
Catalog No.: PC-35334Not For Human Use, Lab Use Only.
Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM.
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Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.
| M.Wt | 571.715 | |
| Formula | C31H45N3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164.
2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616.
3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.
4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21.
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