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Pocapavir

Chemical Structure : Pocapavir

CAS No.: 146949-21-5

Pocapavir (V-073, SCH48973)

Catalog No.: PC-20018Not For Human Use, Lab Use Only.

Pocapavir (V-073, SCH48973) is a potent, selective, antienterovirus inhibitor with IC50 of 0.02 to 0.11 ug/mL, specifically interacts with viral capsid.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pocapavir (V-073, SCH48973) is a potent, selective, antienterovirus inhibitor with IC50 of 0.02 to 0.11 ug/mL, specifically interacts with viral capsid.
Pocapavir (V-073, SCH48973) shows high affinity for binding to poliovirus capsid with Ki of 0.9 nM.
Pocapavir (V-073, SCH48973) demonstrated efficacy in a murine poliovirus model of enterovirus disease.
Pocapavir (V-073, SCH48973) increased the survival of infected mice when it was administered orally at dosages of 3 to 20 mg/kg of body weight/day.
Oral administration of Pocapavir (V-073, SCH48973) also reduced viral titers in the brains of infected mice.

Physicochemical Properties

M.Wt 423.71
Formula C21H17Cl3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-dichloro-2-((4-((2-chloro-4-methoxyphenoxy)methyl)benzyl)oxy)benzene

References

1. Buontempo PJ, et al. Antimicrob Agents Chemother. 1997 Jun;41(6):1220-5.

2. Lentz KN, et al. Structure. 1997 Jul 15;5(7):961-78.

3. Liu HM, et al. Antimicrob Agents Chemother. 2012 Nov;56(11):5568-74.

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