PolQi1

Chemical Structure : PolQi1

CAS No.: 2607139-80-8

Catalog No.: PC-24607Not For Human Use, Lab Use Only.

PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ.

Packing	Price	Stock
2 mg	$158	In stock
5 mg	$288	In stock
10 mg	$458	In stock
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Biological Activity

PolQi1 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 2.48 uM (MH-mediated deletion), targets the polymerase domain of Polϴ.

Physicochemical Properties

M.Wt	448.78
Formula	C18H14ClF5N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Imidazolidinecarboxamide, N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-2-oxo-, (4S)-

References

1. Wimberger, S. et al. Nat Commun. 2023 Aug 14;14(1):4761.

2. Patent WO2021/028643.

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PolQi1

Biological Activity

Physicochemical Properties

References

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