PolQi2

Chemical Structure : PolQi2

CAS No.: 2565638-16-4

Catalog No.: PC-24608Not For Human Use, Lab Use Only.

PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$388	In stock
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Biological Activity

PolQi2 is a specific small molecule DNA polymerase theta (Polϴ) inhibitor with IC50 of 0.238 uM (MH-mediated deletion), inhibits the helicase activity of Polϴ.

Physicochemical Properties

M.Wt	453.90
Formula	C21H16ClN5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((5-Chloropyridin-2-yl)methoxy)-1,3,4-thiadiazol-2-yl)-3-(2-methoxyphenyl)isonicotinamide

References

1. Wimberger, S. et al. Nat Commun. 2023 Aug 14;14(1):4761.

2. Patent WO202/0243459.

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PolQi2

Biological Activity

Physicochemical Properties

References

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