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Chemical Structure : Poziotinib
CAS No.: 1092364-38-9
Catalog No.: PC-44668Not For Human Use, Lab Use Only.
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 100 mg | $428 | In stock | |
| 1 g | Get quote |
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Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.
Poziotinib inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest.
Poziotinib exerts synergistic effects with chemotherapeutic agents.
| M.Wt | 491.3423 | |
| Formula | C23H21Cl2FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]- |
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1. Nam HJ, et al. Cancer Lett. 2011 Mar 28;302(2):155-65.
2. Cha MY, et al. Int J Cancer. 2012 May 15;130(10):2445-54.
3. Kim HJ, et al. Anticancer Drugs. 2012 Mar;23(3):288-97.
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