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Prexasertib

Chemical Structure : Prexasertib

CAS No.: 1234015-52-1

Prexasertib (LY-2606368;LY 2606368;LY2606368)

Catalog No.: PC-45427Not For Human Use, Lab Use Only.

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.

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Biological Activity

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
Prexasertib (LY-2606368)  potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM.
Prexasertib (LY-2606368)  causes replication catastrophe in vitro and in vivo.
Prexasertib (LY-2606368)  shows significant tumor growth inhibition in xenograft tumor models.

Physicochemical Properties

M.Wt 365.3892
Formula C18H19N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 60 mg/mL

Chemical Name/SMILES

2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-

References

1. King C, et al. Mol Cancer Ther. 2015 Sep;14(9):2004-13.

2. Lowery CD, et al. Clin Cancer Res. 2017 Aug 1;23(15):4354-4363.

3. Sen T, et al. Cancer Res. 2017 Jul 15;77(14):3870-3884.

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