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Chemical Structure : Pyrcoumin
Catalog No.: PC-73006Not For Human Use, Lab Use Only.
Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
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Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
Pyrcoumin dose-dependently decreased the expression of Wnt target genes AXIN2, CCND1 and LEF1 in Wnt-activated HEK293 cells.
Pyrcoumin inhibited Wnt pathway activity also in HCT116 cells, did not affect the abundance of β-catenin, or other pathway components such as Axin2 and phosphorylated (Ser33/Ser37/Thr41) β-catenin.
Pyrcoumin impairs the direct interaction of dCTPP1 and USP7.
| M.Wt | 363.369 | |
| Formula | C21H17NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Waldmann H, et al. Angew Chem Int Ed Engl. 2019 Jun 7. doi: 10.1002/anie.201905977.
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