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Chemical Structure : QA-68-ZU81
Catalog No.: PC-49151Not For Human Use, Lab Use Only.
QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC).
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QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC).
QA-68 causes concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells (IC50=1-10 nM for MV4;11 and SKM-1, and IC50=10-100 nM for Kasumi-1-luc +), shows less sensitivity HEL, KO52 and THP-1, showed less sensitivity.
QA-68 more effectively inhibits SKM-1 cell cycle progression than EA-89, affects cell growth, differentiation, and colony formation in AML cells.
| M.Wt | 1169.427 | |
| Formula | C61H72N10O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ellen Weisberg, et al. Blood Cancer J. 2022 Jul 19;12(7):110.
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