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Chemical Structure : QM385
Catalog No.: PC-35829Not For Human Use, Lab Use Only.
QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.
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QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.
QM385 is structurally distinct from SPRi3, does not inhibit a panel of physiologically important targets or closely related reductases.
QM385 potently inhibits BH4 levels in anti-CD3/28-stimulated mouse splenocytes and human PBMCs with IC50 of 35 nM and 74 nM respectively.
QM385 treatment resulted in markedly less proliferation of CD4+ T cells in vitro, oral administration of QM385 to mice for 3 days greatly reduced the number of inflammatory T cells and eosinophils in the ovalbumin-induced and house dust mite (HDM) airway allergic inflammation models.
| M.Wt | 409.373 | |
| Formula | C17H18F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568.
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