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Quinacrine dihydrochloride

Chemical Structure : Quinacrine dihydrochloride

CAS No.: 69-05-6

Quinacrine dihydrochloride (Mepacrine dihydrochloride;SN-390)

Catalog No.: PC-43699Not For Human Use, Lab Use Only.

An antiprotozoal, antirheumatic and intrapleural sclerosing agent.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

An antiprotozoal, antirheumatic and intrapleural sclerosing agent; inhibits histamine N-methyltransferase (HNMT); also strongly induces p53 function, suppresses both basal and inducible activities of NF-kappaB in RCC and other types of cancer cells; promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth.

Prostate Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt 472.8787
Formula C23H32Cl3N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 44 mg/mL

Chemical Name/SMILES

1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride (1:2)

References

1. Horton JR, et al. Structure. 2001 Sep;9(9):837-49.

2. Gurova KV, et al. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53.

3. Khurana A, et al. Oncotarget. 2015 Nov 3;6(34):36354-69.

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