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R-1479

Chemical Structure : R-1479

CAS No.: 478182-28-4

R-1479 (R 1479;4'-Azidocytidine;R1479)

Catalog No.: PC-42589Not For Human Use, Lab Use Only.

A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay).

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10 mg $400 In stock
50 mg $1200 In stock
100 mg $1680 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay); shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at >2 mM; inhibits RNA synthesis mediated by NS5B with IC50 of 320 nM, is the active form of Balapiravir (R-1479).

Physicochemical Properties

M.Wt 284.2288
Formula C9H12N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

Cytidine, 4'-C-azido-

References

1. Smith DB, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.

2. Klumpp K, et al. J Biol Chem. 2006 Feb 17;281(7):3793-9.

3. Ali S, et al. Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69.

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