Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : R-268712
Catalog No.: PC-43290Not For Human Use, Lab Use Only.
R-268712 is a potent, selective, orally active inhibitor of TGF-β type I receptor ALK5 with IC50 of 2.5 nM, >5,000-fold more selectivity than p38 MAPK.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
R-268712 is a potent, selective, orally active inhibitor of TGF-β type I receptor ALK5 with IC50 of 2.5 nM, >5,000-fold more selectivity than p38 MAPK; inhibits the development of renal fibrosis in a dose-dependent manner in a unilateral ureteral obstruction (UUO) model at doses of 1, 3 and 10mg/kg, also reduces proteinuria and glomerulosclerosis significantly with improvement of renal function in glomerulonephritis models.
| M.Wt | 363.3882 | |
| Formula | C20H18FN5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Terashima H, et al. Eur J Pharmacol. 2014 Jul 5;734:60-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
