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Chemical Structure : RA 5557
Catalog No.: PC-38105Not For Human Use, Lab Use Only.
RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.
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RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.
RA 5557 reduced pathologically elevated psychosine concentrations (72-86%) in the midbrain and cerebral cortex in twitcher mice.
RA 5557 decreased galactosylceramides by about 70% in midbrain and cerebral cortex in mutant and wild type animals.
RA 5557 significantly decreased several characteristic inflammatory response markers without causing apparent toxicity to myelin-producing cells in wild type and mutant mice.
RA 5557 decreases in vivo galactosphingolipid biosynthesis in murine Krabbe disease.
| M.Wt | 529.454 | |
| Formula | C20H21F6N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eva Zaccariotto, et al. Biomed Pharmacother. 2022 Mar 12;149:112808.
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