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Chemical Structure : RA608
Catalog No.: PC-72970Not For Human Use, Lab Use Only.
RA608 (RA-608) is a potent, selective, ATP-competitive, orally available CaMKII inhibitor, inhibits human CaMKIIδ, CaMKIIɣ, CaMKIIα, and CaMKIIβ with IC50 of 22, 51, 121, and 1135 nM, respectively.
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RA608 (RA-608) is a potent, selective, ATP-competitive, orally available CaMKII inhibitor, inhibits human CaMKIIδ, CaMKIIγ, CaMKIIα, and CaMKIIβ with IC50 of 22, 51, 121, and 1135 nM, respectively.
RA608 displays a good selectivity profile against a broad panel of 304 human recombinant kinases.
RA608 significantly reduces SR Ca leak in human atrial cardiomyocytes, reduces diastolic tension of human atrial trabeculae, does not affect action potential characteristics; attenuates heart failure in the murine HF model induced by TAC.
| M.Wt | 539.695 | |
| Formula | C28H37N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Julian Mustroph, et al. ESC Heart Fail. 2020 Oct;7(5):2871-2883.
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