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Chemical Structure : RBN3143
CAS No.: 2360853-16-1
Catalog No.: PC-20898Not For Human Use, Lab Use Only.
RBN3143 (RBN-3143) is a potent, selective, NAD+-competitive catalytic inhibitor of PARP14 with IC50 of 4 nM, >300-fold selectivity over other ADP-ribosyltransferase (ART) family members.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $578 | In stock | |
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| 100 mg | Get quote |
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RBN3143 (RBN-3143) is a potent, selective, NAD+-competitive catalytic inhibitor of PARP14 with IC50 of 4 nM, >300-fold selectivity over other ADP-ribosyltransferase (ART) family members.
RBN-3143 broadly suppressed disease phenotypes such as airway mucus, serum-IgE levels, and the accumulation of immune cells and inflammatory cytokines in the BALF in a mouse model of severe, steroid-resistant asthma.
RBN-3143 also suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
RBN-3143 is the first small molecule inhibitor of PARP14 entering clinical trials.
| M.Wt | 449.54 | |
| Formula | C22H28FN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-((1-acetylpiperidin-4-yl)methoxy)-5-fluoro-2-(((tetrahydro-2H-pyran-4-yl)thio)methyl)quinazolin-4(3H)-one |
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1. Niepel M, et, al. European Respiratory Journal 2022 60: 4642.
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