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Chemical Structure : RBP4 antagonist 59
Catalog No.: PC-20717Not For Human Use, Lab Use Only.
RBP4 antagonist 59 is a potent, selective and orally bioavailable retinol-binding protein 4 (RBP4) antagonist with HTRF IC50 of 16 nM.
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RBP4 antagonist 59 is a potent, selective and orally bioavailable retinol-binding protein 4 (RBP4) antagonist with HTRF IC50 of 16 nM.
RBP4 antagonist 59 does not display any off-target pharmacology at KOR or at any other target within a screening panel.
RBP4 antagonist 59 (20 mg/kg per day) reduces circulating levels of adipose-derived RBP4 in the mouse transgenic model of hepatic steatosis.
RBP4 antagonist 59 partially prevents high-fat diet-induced obesity in adi-hRBP4 mice, reduces hepatic free fatty acid and triglyceride levels in obese adi-hRBP4 mice.
| M.Wt | 417.37 | |
| Formula | C20H15F4N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christopher L Cioffi, et al. J Med Chem. 2019 Jun 13;62(11):5470-5500.
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