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Chemical Structure : RETRA
CAS No.: 1036069-26-7
Catalog No.: PC-62777Not For Human Use, Lab Use Only.
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
RETRA increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
| M.Wt | 269.333 | |
| Formula | C11H11NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one |
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1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.
3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.
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