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Chemical Structure : RETRA hydrobromide
Catalog No.: PC-62079Not For Human Use, Lab Use Only.
RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
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RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
| M.Wt | 350.245 | |
| Formula | C11N11NO3S2.HBr | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.
3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.
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