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REV7-IN-1

Chemical Structure : REV7-IN-1

CAS No.: 1979192-13-6

REV7-IN-1 (REV7/REV3L-IN-1)

Catalog No.: PC-28470Not For Human Use, Lab Use Only.

REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.

Physicochemical Properties

M.Wt 371.46
Formula C19H21N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((1-Acetylpiperidin-4-yl)methyl)-5-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one

References

1. Actis ML, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.

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