Chemical Structure : REV7-IN-1
CAS No.: 1979192-13-6
Catalog No.: PC-28470Not For Human Use, Lab Use Only.
REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.
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| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.
| M.Wt | 371.46 | |
| Formula | C19H21N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-((1-Acetylpiperidin-4-yl)methyl)-5-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one |
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1. Actis ML, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.

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