Chemical Structure : REV7 inhibitor C10
CAS No.:
549482-41-9
REV7 inhibitor C10
(Compound 10)
Catalog No.: PC-28474Not For Human Use, Lab Use Only.
REV7 inhibitor C10 (Compound 10) is a small-molecule inhibitor targeting the REV3-binding interface of REV7 (MAD2L2) and disrupting the REV7-REV3 protein-protein interaction (IC50=3.9 uM) within DNA polymerase ζ (Pol ζ).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
REV7 inhibitor C10 (Compound 10) is a small-molecule inhibitor targeting the REV3-binding interface of REV7 (MAD2L2) and disrupting the REV7-REV3 protein-protein interaction (IC50=3.9 uM) within DNA polymerase ζ (Pol ζ).
C10 sensitized HCT116 and HT-29 CRC cells to the microtubule-disrupting agent colchicine, resulting in markedly reduced clonogenic survival.
C10 does not substantially enhance sensitivity to cisplatin.
Combined C10 and colchicine treatment is associated with pronounced alterations in mitotic and post-mitotic nuclear morphology, including condensed/mitotic-like and multinucleated configurations, and increased micronucleus formation.
Combined C10 and colchicine treatment also increases the frequency of cells containing multiple γ-tubulin-positive foci, consistent with disrupted centrosome-associated organization in HT-29 cells.
Physicochemical Properties
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M.Wt
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510.67
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Formula
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C27H30N2O4S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 5-(diethylcarbamoyl)-4-methyl-2-(2-phenyl-2-(phenylthio)acetamido)thiophene-3-carboxylate
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References
1. Guyette M, et al. bioRxiv [Preprint]. 2026 Sep 30:2026.09.29.755408.
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