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Chemical Structure : RG14620
CAS No.: 136831-49-7
Catalog No.: PC-42383Not For Human Use, Lab Use Only.
A potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 4 uM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 50 mg | $224 | In stock | |
| 100 mg | $360 | In stock |
Bulk size, bulk discount!
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A potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 4 uM in cell-free assays; dose-dependently inhibits human gastric cancer cells growth with IC50 of 7 uM; suppresses not only EGF-stimulated cancer cell proliferation in vitro but also tumor growth in nude mice; selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines.
| M.Wt | 275.13272 | |
| Formula | C14H8Cl2N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 26 mg/mL |
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| Chemical Name/SMILES |
3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]- |
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1. Yoneda T, et al. Cancer Res. 1991 Aug 15;51(16):4430-5.
2. Piontek M, et al. Anticancer Res. 1993 Nov-Dec;13(6A):2119-23.
3. Wu CP, et al. Cancer Lett. 2017 Nov 28;409:56-65.
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