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Chemical Structure : RG7112
CAS No.: 939981-39-2
Catalog No.: PC-42750Not For Human Use, Lab Use Only.
RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM).
RG7112 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts. orally bioactive.
| M.Wt | 727.7831 | |
| Formula | C38H48Cl2N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]- |
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1. Tovar C, et al. Cancer Res. 2013 Apr 15;73(8):2587-97.
2. Andreeff M, et al. Clin Cancer Res. 2016 Feb 15;22(4):868-76.
3. Vu B, et al. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9.
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