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Chemical Structure : RGH-122
Catalog No.: PC-21614Not For Human Use, Lab Use Only.
RGH-122 is a potent, selective, and orally bioavailable V1a receptor antagonist with Ki/IC50 of 0.3/0.9 nM (hV1a) respectively, >100-fold selectiive over V2 receptor.
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RGH-122 is a potent, selective, and orally bioavailable V1a receptor antagonist with Ki/IC50 of 0.3/0.9 nM (hV1a) respectively, >100-fold selectiive over V2 receptor.
RGH-122 shows over 6000-fold and over 10 000-fold selectivity over V1b receptors and hERG channels.
RGH-122 (0.5, 1.5, and 5 mg/kg, oral) restored social recognition memory deficit induced by prenatal valproate exposure in male rats after an 8 day treatment regimen.
| M.Wt | 452.94 | |
| Formula | C24H25ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ferenc Baska, et al. J Med Chem. 2024 Jan 2. doi: 10.1021/acs.jmedchem.3c01868.
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