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Chemical Structure : RK-33
Catalog No.: PC-61320Not For Human Use, Lab Use Only.
RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.
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RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.
RK-33 causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
RK-33 exhibits growth inhibitory properties against NCI-60 panel of cell lines with GI50 of <1 uM-7 uM.
RK-33 inhibits Wnt signaling mediated by DDX3, and promotes tumor regression in preclinical models of DDX3-overexpressing lung cancer in combination with radiation.
| M.Wt | 428.44 | |
| Formula | C23H20N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bol GM, et al. EMBO Mol Med. 2015 May;7(5):648-69.
2. Kondaskar A, et al. ACS Med Chem Lett. 2010 Dec 31;2(3):252-256.
3. Heerma van Voss MR, et al. Oncotarget. 2015 Sep 29;6(29):28312-26.
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