Chemical Structure : RNK06395
CAS No.:
RNK06395
(RNK-06395)
Catalog No.: PC-28725Not For Human Use, Lab Use Only.
RNK06395 is a potent orally available chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, ERK5-CHAMP), degrades ERK5 protein in Huh-7 (Dmax=71.3%, DC50 of 50.98 nM), MOLP-8 (Dmax=84.7%, DC50=24.54 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RNK06395 is a potent orally available chaperone-mediated ERK5 degrader (Chaperone-Mediated Protein Degradation, ERK5-CHAMP), degrades ERK5 protein in Huh-7 (Dmax=71.3%, DC50 of 50.98 nM), MOLP-8 (Dmax=84.7%, DC50=24.54 nM).
RNK06395 inhibited tumor growth after oral administration in a dose-dependent manner in Huh-7 and MOLP-8 xenograft tumor models.
Physicochemical Properties
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M.Wt
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932.04
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Formula
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C45H52F3N11O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-((4-(((1r,4r)-4-((5-methyl-11-(methylsulfonyl)-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)cyclohexyl)methyl)piperazin-1-yl)methyl)phenyl)-N-(2,2,2-trifluoroethyl)-4H-1,2,4-triazole-3-carboxamide
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References
1. Xiangcai Yang, et al. Cell Commun Signal. 2026 Feb 3;24(1):157.
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