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Chemical Structure : RO-5963
CAS No.: 1416663-77-8
Catalog No.: PC-60443Not For Human Use, Lab Use Only.
RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $488 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.
RO-5963 stabilizes p53 and activates the p53 pathway in cancer cells, inhibits the binding of p53 to MDM2 and MDMX.
RO-5963 restores p53 transcriptional activity, elevates protein levels of its transcription targets, p21 and MDM2, and overcomes the apoptotic resistance of MDMX-overexpressing cell line, SJSA-X, to nutlin-3.
RO-5963 decreases cell viability and induces cell death.
| M.Wt | 518.902 | |
| Formula | C24H21ClF2N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-2-(4-((6-Chloro-7-methyl-1H-indol-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamide |
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1. Graves B, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.
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