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Chemical Structure : RO 5073012
Catalog No.: PC-61076Not For Human Use, Lab Use Only.
A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors.
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A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models.
| M.Wt | 249.742 | |
| Formula | C13H16ClN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8.
2. Revel FG, et al. Neuropsychopharmacology. 2012 Nov;37(12):2580-92.
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