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RP04340

Chemical Structure : RP04340

CAS No.: 3118096-98-0

RP04340 (RP-04340)

Catalog No.: PC-27988Not For Human Use, Lab Use Only.

RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates.

Physicochemical Properties

M.Wt 1049.16
Formula C56H61F5N10O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(6-(1-(7-(((R)-1-(((7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-4-((S)-1-oxa-6-azaspiro[3.5]nonan-6-yl)pyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)-2,2-difluorocyclopropyl)methyl)-7-azaspiro[3.5]nonan-2-yl)piperidin-4-yl)-5-fluoro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione

References

1. Xiang Ji, et al. J Med Chem. 2026 Aug 27;69(16):19982-19998.

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