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Chemical Structure : RTC-5
CAS No.: 1423077-49-9
Catalog No.: PC-62747Not For Human Use, Lab Use Only.
RTC-5 is a dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 12.6 uM against H1650 lung adenocarcinoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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RTC-5 (PP2A activator RTC-5, TRC-382) is a dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 12.6 uM against H1650 lung adenocarcinoma cells.
RTC-5 (PP2A activator RTC-5, TRC-382) significantly decreases tumor growth in H1650 xenograft in mice.
| M.Wt | 510.956 | |
| Formula | C24H22ClF3N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-4-(trifluoromethoxy)benzenesulfonamide |
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1. Kastrinsky DB, et al. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34.
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