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Chemical Structure : RTI-118
Catalog No.: PC-21472Not For Human Use, Lab Use Only.
RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.
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RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.
RTI-118 (5–30 mg/kg i.p.) produced a dose-dependent and nearly complete elimination of cocaine self-administration, and was more potent and efficacious to reduce cocaine self-administration than food-maintained responding.
RTI-118 (1–20 mg/kg i.p.) also blocked cocaine, cue-, and stress-induced reinstatement of extinguished cocaine self-administration.
| M.Wt | 448.57 | |
| Formula | C26H32N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang Y, et al. Bioorg Med Chem Lett. 2008;18:4064–4067.
2. Julie S Bonano, et al. Eur J Pharmacol. 2014 Nov 15:743:98-105.
3. Christopher D Schmoutz, et al. Pharmacol Biochem Behav. 2012 Dec;103(2):332-7.
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