RTx-152 | DNA Polθ inhibitor | Probechem Biochemicals

Chemical Structure : RTx-152

CAS No.: 3035072-48-8

RTx-152 (RTx152)

Catalog No.: PC-24443Not For Human Use, Lab Use Only.

RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells.

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2 mg	$248	In stock
5 mg	$398	In stock
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Biological Activity

RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells.
RTx-152 also exhibits synergistic activity with Olaparib in BRCA2-null cells.

Physicochemical Properties

M.Wt	479.35
Formula	C20H16F7N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-(4-fluorophenyl)-N-methyl-, 2-(3-methyl-2-oxo-1-imidazolidinyl)-4,6-bis(trifluoromethyl)phenyl ester

References

1. Fried W, et al. Nat Commun. 2024 Apr 5;15(1):2862.

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RTx-152 (RTx152)

Biological Activity

Physicochemical Properties

References

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