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Chemical Structure : RU-SKI 43
CAS No.: 1043797-53-0
Catalog No.: PC-45463Not For Human Use, Lab Use Only.
RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
RU-SKI 43 is specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src.
RU-SKI 43 reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.
| M.Wt | 386.5508 | |
| Formula | C22H30N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]- |
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1. Petrova E, et al. Nat Chem Biol. 2013 Apr;9(4):247-9.
2. Petrova E, et al. Oncogene. 2015 Jan 8;34(2):263-8.
3. Matevossian A, et al. Mol Cancer. 2015 Apr 1;14:72.
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