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Chemical Structure : RUNX1/ETO inhibitor 7.44
Catalog No.: PC-49279Not For Human Use, Lab Use Only.
RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM.
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RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM.
RUNX1-ETO inhibitor 7.44 targets the interaction between the NHR2 domain of RUNX1/ETO, interferes with NHR2 tetramer stability and leads to an increase in the dimer population of NHR2.
RUNX1-ETO inhibitor 7.44 binds with both heteroaromatic moieties to NHR2 and interacts with or leads to conformational changes in the N-termini of the NHR2 tetramer.
RUNX1-ETO inhibitor 7.44 has favorable physicochemical, pharmacokinetic, and toxicological properties, shows anti-leukemic effects.
| M.Wt | 342.303 | |
| Formula | C18H14O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mohanraj Gopalswamy, et al. Sci Rep. 2022 Aug 19;12(1):14158.
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