Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : RX-207
Catalog No.: PC-20580Not For Human Use, Lab Use Only.
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.
RX-207 (50 mg/kg) inhibited neutrophil migration into the peritoneal cavity by 37% in a mouse model of thioglycollate-induced peritonitis.
Intramuscular (i.m.) injection of RX-207 (1 mg/kg, 0.1 mL) inhibited carrageenan-induced paw edema in mice (32%).
RX-207 (30 uM) inhibited binding of the pro-inflammatory chemokine, MCP-3, to heparin, a highly sulfated form of the cell surface GAG, heparan sulfate.
RX-207 (30 μM) inhibited binding of the pro-inflammatory chemokine, IP-10, to the extracellular matrix GAG, chondroitin sulfate.
| M.Wt | 382.51 | |
| Formula | C22H30N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Stefan Juhas, et al. Inflammation. 2018 Feb;41(1):307-314.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
