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Chemical Structure : RX-37
Catalog No.: PC-60935Not For Human Use, Lab Use Only.
RX-37 (RX37) is a potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4.
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RX-37 (RX37) is a potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4.
RX-37 shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM).
RX-37 potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).
| M.Wt | 413.481 | |
| Formula | C24H23N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39.
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