Retro-2.1

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Chemical Structure : Retro-2.1

Catalog No.: PC-27430Not For Human Use, Lab Use Only.

Retro-2.1 is a small molecule inhibitor of retrograde transport, protects human cells against ricin and Stx by blocking retrograde toxin transport at the early endosomes-TGN interface, efficiently inhibits SARS-CoV-2 replication, inhibits JC polyomavirus (JCPyV) with EC50 of 3.9 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	435.54
Formula	C23H18FN3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

References

1. Vinck R, et al. Int J Mol Sci. 2022 Nov 23;23(23):14611.

2. Holwerda M, et al. Microorganisms. 2020 Nov 26;8(12):1872.

3. Gupta N, et al. ACS Med Chem Lett. 2013 Dec 4;5(1):94-7.

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Retro-2.1

Biological Activity

Physicochemical Properties

References

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