Catalog No.: PC-27432Not For Human Use, Lab Use Only.
Retro-2(cycl) (Retro-2 cycl) is a small molecule inhibitor of host retrograde trafficking, inhibits ricin and Shiga-like toxins (SLTs), inhibits infection by JCPyV, BKPyV, and simian virus 40 (SV40).
Retro-2(cycl) (Retro-2 cycl) is a small molecule inhibitor of host retrograde trafficking, inhibits ricin and Shiga-like toxins (SLTs), inhibits infection by JCPyV, BKPyV, and simian virus 40 (SV40). Retro-2(cycl) inhibits retrograde transport of polyomaviruses to the endoplasmic reticulum. Retro-2(cycl) likely inhibits polyomaviruses in a way similar to its ricin and SLT inhibition, suggesting an overlap in the cellular host factors used by bacterial toxins and polyomaviruses. Retro-2(cycl) protects cells from infection with JCPyV and BKPyV by inhibiting intracellular viral transport. Retro-2(cycl) significantly reduced body weight loss and improved clinical scores and survival rates for O104:H4-infected mice.
