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Risedronate

Chemical Structure : Risedronate

CAS No.: 105462-24-6

Risedronate (Risedronic acid)

Catalog No.: PC-26883Not For Human Use, Lab Use Only.

Risedronate (Risedronic acid) is a bisphosphonate and potent antiresorptive agent, induces apoptosis, inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins, inhibits blood-stage Plasmodium falciparum with IC50 of 20.3 uM, also is a small-molecule DKK1 antagonist that attenuates DKK1-mediated LRP6 sequestration, restores Wnt/β-catenin signaling.

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Biological Activity

Risedronate (Risedronic acid) is a bisphosphonate and potent antiresorptive agent, induces apoptosis, inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins, inhibits blood-stage Plasmodium falciparum with IC50 of 20.3 uM, also is a small-molecule DKK1 antagonist that attenuates DKK1-mediated LRP6 sequestration, restores Wnt/β-catenin signaling.

Physicochemical Properties

M.Wt 283.11
Formula C7H11NO7P2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1-Hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid

References

1. Manandhar S, et al. Eur J Pharmacol. 2026 May 14;1026:178971.

2. Jordao FM, et al. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

3. Fujita H, et al. Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):78-84.

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