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WAY-262611 (WAY262611) is a potent, orally active and Wnt/β-catenin pathway agonist with EC50 of 0.63 nM, via inhibition of dickkopf-1 (DKK-1); increases bone formation rate in ovariectomized rats; inhibits cell migration of fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis.



524-26-5 IIIC3 (Gallocyanine;Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5 uM for reversing DKK1 CM-mediated Wnt inhibition; inhibits the binding of DKK1-alkaline phosphatase (AP) to HEK293 cells expressing the wild-type LRP5 or LRP5 mutant with IC50 of 3 uM; reduces basal blood-glucose concentrations and improves glucose tolerance in mice.

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