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Chemical Structure : Ro 08-2750
CAS No.: 37854-59-4
Catalog No.: PC-61912Not For Human Use, Lab Use Only.
Ro 08-2750 (Ro 082750) is a potent, selective, non-peptide nerve growth factor (NGF) inhibitor that binds to NGF dimer with Kd of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 50 mg | $418 | In stock | |
| 100 mg | $728 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Ro 08-2750 (Ro 082750) is a potent, selective, non-peptide nerve growth factor (NGF) inhibitor that binds to NGF dimer with Kd of 1 uM.
Ro 08-2750 selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at > 5 uM.
Ro 08-2750 inhibits NGF-induced programmed cell death in SK-N-MC cells.
| M.Wt | 270.24 | |
| Formula | C13H10N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde |
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1. Niederhauser O, et al. J Neurosci Res. 2000 Aug 1;61(3):263-72.
2. Eibl JK, et al. Eur J Pharmacol. 2013 May 15;708(1-3):30-7.
3. Chakravarthy R, et al. Biochem Biophys Res Commun. 2016 Sep 30;478(4):1541-7.
4. Li B, et al. Oncotarget. 2016 Dec 6;7(49):81026-81048.
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