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Chemical Structure : Ro 48-8071 fumarate
CAS No.: 189197-69-1
Catalog No.: PC-45493Not For Human Use, Lab Use Only.
A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 50 mg | $208 | In stock | |
| 100 mg | $352 | In stock |
Bulk size, bulk discount!
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A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.
Dyslipidemia
Preclinical
| M.Wt | 564.4406 | |
| Formula | C27H31BrFNO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 55 mg/mL |
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| Chemical Name/SMILES |
Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1) |
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1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
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